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US 11,440,918 B2Granted
p38α mitogen-activated protein kinase inhibitors
AssigneeGen1E Lifesciences Inc.
InventorsAdam Galan, Wendy Luo, Ritu Lal
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Abstract
Disclosed herein are p38α mitogen-activated protein kinase inhibitors, pharmaceutical compositions thereof, and therapeutic methods of using the p38α mitogen-activated protein kinase inhibitors.
Claims29
A compound having the structure of Formula (1):
- or a pharmaceutically acceptable salt thereof, wherein,
- R1 is selected from C1-4 alkanediyl and C1-4 heteroalkanediyl;
- and
- R2 is a moiety having the structure of Formula (2d):
- wherein,
- each of A1 and A2 is independently selected from —CH2— and —C(═O)—;
- each n is independently selected from 1, 2, and 3;
- and
- X is —NR3— and R3 is —C(═O)—CH3.
6 more elements
A compound having the structure of Formula (1):
- or a pharmaceutically acceptable salt thereof, wherein,
- R1 is C1-4 alkanediyl;
- and
- R2 is a moiety having the structure of Formula(2d
- wherein,
- each n is independently selected from, 1, 2, and 3;
- each of A1 and A2 is independently selected from —CH2 and —C(═O)—,
- and at least one of A1 and A2 is —C(═O)—;
- and
- X is —NR3—, wherein R3 is selected from hydrogen, C1-6 alkyl, and substituted C1-6 alkyl.
7 more elements
A compound having the structure of Formula (1):
- or a pharmaceutically acceptable salt thereof, wherein,
- R1 is selected from C1-4 alkanediyl, C1-4 heteroalkanediyl, substituted C1-4 alkanediyl, and substituted C1-4 heteroalkanediyl;
- and
- R2 is a moiety having the structure of Formula (2d):
- wherein,
- one n is 1 and the other n is selected from 2 and 3;
- each of A1 and A2 is independently selected from —CH2— and —C(═O)—, and at least one of A1 and A2 is —C(═O)—;
- and
- X is —NR3—, wherein R3 is selected from hydrogen, C1-6 alkyl, and substituted C1-6 alkyl.
6 more elements
Dependencies are inferred from the claim text.