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US 11,440,903 B2Granted
Salt form and crystal form of compound as FGFR4 inhibitor and preparation method thereof
AssigneesGuangdong Zhongsheng Pharmaceutical Co., Ltd, Guangdong Xianqiang Pharmaceutical Co., Ltd
InventorsChaofeng Long, Yang Zhang, Zhengxia Chen, Xiaoxin Chen, Zhuowei Liu, Meibi Dai, Zhiqiang Liu, Shuhui Chen
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Abstract
The present invention provides a salt form, a crystal form, and a preparation method of a compound as an FGFR4 inhibitor and medical uses thereof.
Claims26
A crystal form A, B, C or D of the compound represented by formula (I),
- wherein (i) the X-ray powder diffraction pattern of the crystal form A has characteristic diffraction peaks at the following 2θ angles:
- 5.58±0.2°, 12.43±0.2°, 14.56±0.2°, 18.47±0.2°, 20.23±0.2°, 21.31±0.2°, 22.97±0.2°, 25.44±0.2°;
- (ii) the X-ray powder diffraction pattern of the crystal form B has characteristic diffraction peaks at the following 2θ angles:
- 9.27±0.2°, 12.59±0.2°, 15.21±0.2°, 15.98±0.2°, 18.47±0.2°, 20.90±0.2°, 21.78±0.2°, 27.69±0.2°;
- (iii) the X-ray powder diffraction pattern of the crystal form C has characteristic diffraction peaks at the following 2θ angles:
- 4.35±0.2°, 8.38±0.2°, 10.50±0.2°, 12.25±0.2°, 12.82±0.2°, 13.45±0.2°, 16.36±0.2°, 18.65±0.2°;
- and
- (iv) the X-ray powder diffraction pattern of the crystal form D has characteristic diffraction peaks at the following 2θ angles:
- 5.68±0.2°, 12.53±0.2°, 14.68±0.2°, 18.55±0.2°, 20.33±0.2°, 21.41±0.2°, 23.05±0.2°, 25.52±0.2°.
6 more elements
A compound represented by formula (II) or crystal form E or F thereof,
- wherein the X-ray powder diffraction pattern of the crystal form E has characteristic diffraction peaks at the following 2θ angles:
- 5.95±0.2°, 11.77±0.2°, 12.53±0.2°, 18.53±0.2°, 19.28±0.2°, 21.12±0.2°, 22.42±0.2°, 25.76±0.2°;
- and
- the X-ray powder diffraction pattern of the crystal form F has characteristic diffraction peaks at the following 2θ angles:
- 6.04±0.2°, 9.21±0.2°, 12.02±0.2°, 12.51±0.2°, 15.88±0.2°, 18.35±0.2°, 20.84±0.2°, 21.67±0.2°.
2 more elements
A compound represented by formula (III) or crystal form G thereof,
- wherein the X-ray powder diffraction pattern of the crystal form G has characteristic diffraction peaks at the following 2θ angles:
- 5.86±0.2°, 11.62±0.2°, 12.31±0.2°, 19.22±0.2°, 20.03±0.2°, 22.81±0.2°, 23.68±0.2°, 24.75±0.2°.
Dependencies are inferred from the claim text.