Isoquinoline compounds, methods for their preparation, and therapeutic uses thereof in conditions associated with the alteration of the activity of beta galactosidase

A compound of formula (I):

• or a salt or solvate thereof,
• wherein:
• each of A1 is independently selected from the group consisting of nitrogen and CH;
• and
• each of A2 and A3 is independently selected from the group consisting of nitrogen, CH, and C(R6);
• wherein
• each A1 is CH and each of A2 and A3 is independently selected from CH and C(R6), provided that only one of A2 and A3 is C(R6);
• or
• exactly one of A2 and A3 is C(R6) and no less than one and no more than two of A1, A2, and A3 are nitrogen;
• R1, R2, and R3 are each independently selected from the group consisting of hydrogen, halogen, —CN, —ORb, and —C1-4 alkyl, wherein said —C1-4 alkyl group is optionally substituted by 1, 2 or 3 independently selected halogen atoms, with the proviso that at least one R1, R2, and R3 is other than hydrogen;
• R6 is —B—NH—R7;
• B is —CO— or —SO2—;
• each R4 is independent selected from the group consisting of halogen, —C1-4 alkyl, —C1-4 alkoxy, —CN and hydroxy;
• n has a value selected from 0, 1 or 2;
• R5 is hydrogen or —C1-4 alkyl;
• R7 is selected from the group consisting of —C1-4 alkyl, —C3-10 cycloalkyl, —C1-4 alkyl-C3-10 cycloalkyl, —C6-10 aryl, —C1-4 alkyl-C6-10 aryl, (5- to 10-membered)-C1-9 heteroaryl, —C1-4 alkyl-(5- to 10-membered)-C1-9 heteroaryl, (5- to 10-membered)-C1-9 heterocyclyl, and —C1-4 alkyl-(5- to 10-membered)-C1-9 heterocyclyl;
• said alkyl, cycloalkyl, alkylcycloalkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, heterocyclyl, and alkylheterocyclyl groups optionally being substituted with 1, 2, or 3 groups independently selected from the group consisting of halogen, hydroxyl, —CN, —ORb, —SRb, —N(Rb)2, —C1-4alkyl optionally substituted with 1, 2, or 3 halogen atoms, optionally substituted C6-10 aryl, optionally substituted (5- to 10-membered)-C1-9 heteroaryl, and (5- to 10-membered)-C1-9 heterocyclyl;
• said cycloalkyl, alkylcycloalkyl, aryl, alkylaryl, heteroaryl, alkylheteroaryl, heterocyclyl, and alkylheterocyclyl is optionally fused to a further (second) ring, and
• each Rb is independently hydrogen, —C1-4 alkyl, —C3-10 cycloalkyl, or (5- to 10-membered)-C1-9 heterocyclyl;
• said alkyl, cycloalkyl or heterocyclyl groups optionally being substituted by 1, 2 or 3 fluorine atoms.