Substituted 1,2,3,4-tetrahydroquinolines as inhibitors of repair enzyme 8-oxoguanine deoxyribonucleic acid glycosylase activity

A compound of formula ABCDE:

• wherein:
• A is R1;
• B is 1,2,3,4-tetrahydroquinolin-1,7-diyl;
• C is —NHS(O)2—;
• D is —R4—;
• E is R5;
• R1 is C(O)R10;
• R4 is phenylene;
• wherein the phenylene is optionally substituted with 1 or more substituents independently selected from the group consisting of D, halogen, B(OR)2, CN, alkyl, haloalkyl, C(O)R, C(O)N(R)2, C(O)OR, NC, NCO, NCS, N3, NO2, N(R)2, NRC(O)R, NRC(O)N(R)2, NRC(O)OR, NRS(O)2R, NRS(O)2N(R)2, OCN, OC(O)R, OC(O)N(R)2, ONO2, OP(O)(OR)2, OR, SCN, SR, S(O)R, S(O)2R, S(O)2N(R)2, S(O)2OR, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
• R5 is phenyl;
• wherein the phenyl is optionally substituted with 1 or more substituents independently selected from the group consisting of D, halogen, B(OR)2, CN, alkyl, alkenyl, alkynyl, C(O)R, C(O)N(R)2, C(O)OR, NC, NCO, NCS, N3, NO2, N(R)2, NRC(O)R, NRC(O)N(R)2, NRC(O)OR, NRS(O)2R, NRS(O)2N(R)2, OCN, OC(O)R, OC(O)N(R)2, ONO2, OP(O)(OR)2, OR, SCN, SR, S(O)R, S(O)2R, S(O)2N(R)2, S(O)2OR, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
• R10 is C1-4 alkyl, C1-4 alkylene-aryl, cyclopropyl, or cyclobutyl;
• wherein the C1-4 alkyl of R10 is optionally substituted with 1 or more substituents independently selected from the group consisting of D, halogen, B(OR)2, CN, NCS, N3, NO2, N(R)2, ONO2, OP(O)(OR)2, OR, SCN, SR, S(O)2R, and S(O)2OR;
• wherein the aryl of the C1-4 alkylene-aryl is optionally substituted with 1 or more substituents independently selected from the group consisting of D, halogen, B(OR)2, CN, alkyl, NCS, N3, NO2, N(R)2, ONO2, OP(O)(OR)2, OR, SCN, SR, S(O)2R, and S(O)2OR;
• wherein the cyclopropyl of R10 is optionally substituted with 1 CH3 substituent and/or optionally further substituted with 1 or more additional substituents independently selected from the group consisting of D, halogen, B(OR)2, CN, NCS, N3, NO2, N(R)2, ONO2, OP(O)(OR)2, OR, SCN, SR, S(O)2R, and S(O)2OR;
• wherein the CH3 substituent of the cyclopropyl of R10 is optionally substituted with 1 or more substituents independently selected from the group consisting of D and halogen;
• and
• wherein the cyclobutyl of R10 is optionally substituted with 1 or more substituents independently selected from the group consisting of D, halogen, B(OR)2, CN, NCS, N3, NO2, N(R)2, ONO2, OP(O)(OR)2, OR, SCN, SR, S(O)2R, and S(O)2OR;
• and
• each R is independently H, D, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, cyclopropyl, or cyclobutyl, wherein each C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, cyclopropyl, and cyclobutyl is optionally and independently substituted with 1 or more substituents independently selected from the group consisting of D, halogen, B(OH)2, B(OC1-4 alkyl)2, CN, NCS, N3, NO2, NH2, NHC1-4alkyl, N(C1-4alkyl)2, ONO2, OP(O)(OH)2, OP(O)(OC1-4 alkyl)2, OH, OC1-4 alkyl, SCN, SH, SC1-4 alkyl, S(O)2H, S(O)2C1-4 alkyl, S(O)2OH, S(O)2OC1-4 alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
• or
• each R, taken together with the atom(s) to which they are attached, optionally and independently forms a ring.