Anti-inflammatory compound, and preparation and use thereof

An anti-inflammatory compound, which is a compound having a structure shown below:

• wherein RA is hydrogen, alkyl, or aryl, and in the above groups one or more hydrogen atom(s) attached to carbon in the groups is/are optionally substituted with alkyl, cycloalkyl, aryl, or halogen;
• RB is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, aryl, alkenyl, or alkynyl, and in the above groups one or more hydrogen atom(s) attached to carbon in the groups is/are optionally substituted with alkyl, cycloalkyl, heterocycloalkyl, aryl, or halogen, and one or more carbon atom(s) in the groups is/are optionally replaced with sulfur, sulfoxide, sulfone, or sulfonyl;
• RC is hydrogen, alkyl, halogen, or alkoxy;
• RD1 is hydrogen, oxo, imino, hydroxy, cyano, amino, amido, alkyl, aryl, an ester group, carboxyl, alkenyl, or alkynyl, and in the above groups one or more hydrogen atom(s) attached to carbon/oxygen/nitrogen in the groups is/are optionally substituted with alkyl, cycloalkyl, alkynyl, alkenyl, aryl, halogen, sulfonyl, a sulfoxide group, or an ether group, and one or more carbon atom(s) in the groups is/are replaced optionally with sulfur, sulfoxide, sulfone, or sulfonyl;
• C1-RD1 bond is a single bond or a double bond;
• RD2 is hydrogen, cyano, alkyl, cycloalkyl, aryl, or carboxyl, and in the above groups one or more hydrogen atom(s) attached to carbon/oxygen/nitrogen in the group is/are optionally substituted with alkyl, cycloalkyl, alkynyl, alkenyl, aryl, halogen, sulfonyl, or a sulfoxide group;
• G1 is a single bond, a double bond or a ring, that comprises C1 and C2;
• and
• RE is hydrogen, alkyl, or halogen,
• wherein when RD1 is aryl, it is unsubstituted aryl, and when RD2 is aryl, it is unsubstituted aryl.