Method for processing solutions of biomolecules
AssigneeFujifilm Diosynth Biotechnologies UK Limited
InventorsCharles Heise, Tibor Nagy
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Abstract
Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means for mixing at least two liquids comprising a multiple inlet flow-controller, the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device configured in single-pass mode.
Claims8
Apparatus for in-line liquid exchanging a biomolecule-containing liquid comprising a means for mixing comprising a multiple inlet flow-controller further comprising two or more variable flow inlet valves for mixing at least two liquids, wherein the variable flow inlet valves are controlled to be cycled between a position achieving a first, relatively low flow rate wherein the liquid remains able to flow, or flow is prevented and at least a second, higher flow rate, the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device configured in single-pass mode.
Apparatus for liquid exchanging a biomolecule-containing liquid comprising:
- a) a multiple inlet flow-controller comprising:
- i) a first inlet for a first liquid medium comprising a biomolecule;
- ii) at least a second inlet for a second liquid medium;
- iii) an outlet in fluid connection with a tangential flow filtration device;
- and
- b) a means for imparting flow of the liquids through the flow-controller and the tangential flow filtration device, and
- c) a means for controlling the flow through the tangential flow filtration device such that the flow is cycled between a position achieving a first, relatively low flow rate wherein the liquid remains able to flow, or flow is prevented and at least a second, higher flow rate.
Dependencies are inferred from the claim text.