Protein activity modification
AssigneeImpulse Dynamics NV
InventorsBenny Rousso, Yuval Mika, Hani N. Sabbah, Shlomo Ben-Haim
Life of this patent
Estimating the term…
Abstract
A method of modifying cardiac tissue behavior, comprising applying a therapeutically effective electric field having an effect of modifying protein activation levels of at least one protein, and repeatedly applying the field at time intervals timed to increase the activation levels of the at least one protein beyond an activation level achieved by natural and/or paced excitation of the muscle without the application, to an extent about at least as high as a decay of the activation between applications of the field.
Claims24
A method of therapy location placement for therapy of a tissue, comprising:
- selecting a location in the tissue based on a protein activity level at the location;
- and
- applying a therapy to the location according to said selecting,
- wherein said selecting a location based on a protein activity level comprises one or both of:
- (a) measuring protein activity by applying a test therapy to said or another location in the heart and measuring protein activity or an indication thereof, due to said test therapy;
- and
- (b) estimating the effect of a change in protein activity level of tissue at said location using a model of propagation of effect cascading in said heart;
- and
- selecting the location based on said measuring or estimating,
- wherein the method further comprises:
- deciding on suitability of a location for therapy application by applying a test therapy and deciding on suitability based on an effect on the protein activity levels of said test therapy;
- selecting a first electrical field parameter that causes an increase in phosphorylation, wherein said applying includes applying an electric field according to said first parameter to thereby cause said increase in phosphorylation and thereby change said protein activity level;
- choosing a target modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation;
- and wherein said therapy is selected to achieve said modification;
- measuring an efficacy of achieving said modification with said therapy;
- further selecting a second electric stimulation parameter for achieving said modification over a longer time frame;
- and
- stimulating said tissue with a second electrical field having said second parameter.
Dependencies are inferred from the claim text.