Ingestible device for delivery of therapeutic agent to the gastrointestinal tract

A method of treating a disease or condition in a subject in need thereof, the method comprising:

• trans-epithelially administering a dispensable substance to the gastrointestinal (GI) tract of the subject, wherein the trans-epithelial administration comprises:
• orally administering an ingestible device comprising the dispensable substance to the subject, wherein the ingestible device is configured for trans-epithelial delivery of the dispensable substance to the GI tract of the subject, and the dispensable substance comprises a pharmaceutical formulation comprising a therapeutically effective amount of a glucagon receptor agonist or a glucagon-like peptide-1 (GLP-1) receptor agonist;
• and releasing the dispensable substance from the ingestible device as at least one jet to a desired location of the GI tract of the subject;
• wherein the desired location of the GI tract is the small intestine, wherein the trans-epithelial administration directly delivers the dispensable substance to the submucosa of the GI tract of the subject, and wherein the disease or condition is responsive to treatment with the glucagon receptor agonist or GLP-1 receptor agonist.