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US 11,439,728 B2Granted
Process for coating a biomedical implant with a biocompatible polymer and a biomedical implant therefrom
AssigneeCouncil of Scientific and Industrial Research
InventorsAbhijit Pravin Shete, Anuya Amol Nisal, Ashish Kishore Lele
Life of this patent
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Abstract
The present invention disclosed a process to coat the surface of flexible polymeric implant with biocompatible polymer such that the coating does not crack when the implant is subjected to mechanical forces such as tension, torsion or bending while retaining the inherent properties of the coated polymer.
Claims20
A process for obtaining an implant with a biocompatible polymer coating, said process consisting of:
- (a) dipping an implant in a solution comprising a first biocompatible polymer to obtain an implant with a wet dip coating comprising the first biocompatible polymer;
- and
- (b) electrospinning a second biocompatible polymer onto the implant with the wet dip coating of step (a) to obtain an implant with a biocompatible polymer coating comprising the first biocompatible polymer and electrospun fibers of the second biocompatible polymer;
- wherein
- a portion of the fibers of the second biocompatible polymer are embedded into the dip coating and another portion of the fibers of the second biocompatible polymer are not embedded into the dip coating, and
- the biocompatible polymer coating remains intact, without the formation of cracks or tears after application of a mechanical force selected from the group consisting of bending, tensile stress, compression and torsion.
3 more elements
A process for coating the surface of a polydimethylsiloxane (PDMS) implant with a silk fibroin layer, said process consisting of:
- a) dipping a polydimethylsiloxane (PDMS) implant in a solution comprising regenerated silk fibroin to obtain a wet PDMS implant with a regenerated silk fibroin coating;
- b) placing the wet PDMS implant with the regenerated silk fibroin coating of step (a) on a collector of an electro-spinning system;
- c) dissolving lyophilized silk fibroin (SF), and optionally an antibiotic, in Hexafluroisopropanol (HFIP) to obtain a SF-HFIP solution;
- d) using the SF-HFIP solution of step (c) for electrospinning silk fibroin fibers onto the wet PDMS implant with the regenerated silk fibroin coating of step (b) and;
- e) randomizing deposition of the electrospun silk fibroin fibers by aid of syringe translation and/or collector translation and/or rotation to obtain the PDMS implant with a silk fibroin layer comprising the regenerated silk fibroin coating and the silk fibroin fibers;
- wherein
- a portion of the silk fibroin fibers are embedded into the regenerated silk fibroin coating and another portion of the silk fibroin fibers are not embedded into the silk fibroin coating, and
- the silk fibroin layer remains intact, without the formation of cracks or tears after application of a mechanical force selected from the group consisting of bending, tensile stress, compression and torsion.
5 more elements
Dependencies are inferred from the claim text.