Bioresorbable embolization microspheres
AssigneeRegents of the University of Minnesota
InventorsJafar Golzarian, Lihui Weng
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Abstract
The present disclosure is generally directed to an embolic material which, in some embodiments, may be in the form of a microsphere or a plurality of microspheres. The embolic material generally comprises carboxymethyl chitosan (CCN) crosslinked with carboxymethyl cellulose (CMC). In some embodiments, the embolic material may further comprise a therapeutic agent, such as doxorubicin.
Claims17
A microsphere, comprising:
- carboxymethyl chitosan crosslinked with carboxymethyl cellulose, wherein a crosslinking density between the carboxymethyl chitosan and the carboxymethyl cellulose results in a fracture strain of the microsphere between about 70% and about 90%, and further defines a microsphere diameter between about 50 micrometers and about 2200 micrometers;
- and
- a therapeutic agent.
A microsphere comprising carboxymethyl chitosan crosslinked with carboxymethyl cellulose, wherein a crosslinking density between the carboxymethyl chitosan and the carboxymethyl cellulose results in a fracture strain of the microsphere between about 70% and about 90%, and further defines a microsphere diameter between about 50 micrometers and about 2200 micrometers, and wherein the microsphere has a compressibility sufficient to permit the microsphere to be introduced through a catheter or syringe.
A microsphere comprising carboxymethyl chitosan crosslinked with carboxymethyl cellulose, wherein a crosslinking density between the carboxymethyl chitosan and the carboxymethyl cellulose results in a fracture strain of the microsphere between about 70% and about 90%, and wherein the microsphere has a diameter between about 50 micrometers and about 2200 micrometers;
- and
- a therapeutic agent within the microsphere.
Dependencies are inferred from the claim text.