Compositions and methods to detect GLUA1 in brain and to identify the presence of GLUA1-mediated post-traumatic stress disorder and other neurological disorders

A method of detecting GluA1 levels, or GluA1-containing, GluA2-lacking AMPAR levels, in a region of interest of a subject, comprising:

• a. administering to the subject a first amount of a radiolabeled composition comprising at least one ligand of GluA1 or of a GluA1-containing, GluA2-lacking AMPAR, labeled with a radioactive isotope, wherein the radiolabeled composition comprises any of the following structures:
• or pharmaceutically acceptable salts thereof, wherein the F is an [18F] radioisotope;
• b. subjecting at least the region of interest of the subject to radiological imaging capable of detecting radioactive emissions from an amount of the radiolabeled composition;
• and
• c. determining or quantifying, based at least in part upon the radiological imaging, an amount of radioactive emissions corresponding to a second amount of the radiolabeled composition that is in the region of interest after administration of the first amount.