Influenza peptides and compositions
AssigneePepTcell Limited
InventorsGregory A. Stoloff, Wilson Romero Caparros-Wanderley
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Abstract
The present specification discloses recombinant nucleic acid constructs encoding an immunogenic multiepitope polypeptide comprising two or more polypeptides, recombinant nucleic acid constructs encoding at least two epitopes from two or more internal proteins of influenza virus, compositions comprising such recombinant nucleic acid constructs and methods of eliciting a T cell immune response against an influenza virus in a vertebrate using such recombinant nucleic acid constructs and compositions.
Claims21
A polypeptide composition, the composition comprising an adjuvant and one or more isolated polypeptides, each of the one or more isolated polypeptides being from 8 to 50 amino acids in length,
- wherein the one or more isolated polypeptides include
- a polypeptide comprising an amino acid sequence with 95% or more sequence identity to the amino acid sequence of SEQ ID NO:
- 1 or a fragment of SEQ ID NO:
- 1 having 8 or more consecutive amino acids from the amino acid sequence of SEQ ID NO:
- 1,
- a polypeptide comprising an amino acid sequence with 95% or more sequence identity to the amino acid sequence of SEQ ID NO:
- 2 or a fragment of SEQ ID NO:
- 2 having 8 or more consecutive amino acids from the amino acid sequence of SEQ ID NO:
- 2,
- a polypeptide comprising an amino acid sequence with 95% or more sequence identity to the amino acid sequence of SEQ ID NO:
- 3 or a fragment of SEQ ID NO:
- 3 having 8 or more consecutive amino acids from the amino acid sequence of SEQ ID NO:
- 3,
- a polypeptide comprising an amino acid sequence with 95% or more sequence identity to the amino acid sequence of SEQ ID NO:
- 4 or a fragment of SEQ ID NO:
- 4 having 8 or more consecutive amino acids from the amino acid sequence of SEQ ID NO:
- 4,
- a polypeptide comprising an amino acid sequence with 95% or more sequence identity to the amino acid sequence of SEQ ID NO:
- 5 or a fragment of SEQ ID NO:
- 5 having 8 or more consecutive amino acids from the amino acid sequence of SEQ ID NO:
- 5, and
- a polypeptide comprising an amino acid sequence with 95% or more sequence identity to the amino acid sequence of SEQ ID NO:
- 6 or a fragment of SEQ ID NO:
- 6 having 8 or more consecutive amino acids from the amino acid sequence of SEQ ID NO:
- 6,
- wherein, the one or more polypeptides are immunogenic to one or more influenza strains in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the one or more isolated polypeptides are not a complete influenza virus protein.
A polypeptide composition, the composition comprising an adjuvant and one or more isolated polypeptides, each of the one or more isolated polypeptides being from 8 to 50 amino acids in length,
- wherein the one or more isolated polypeptides include
- a polypeptide comprising an amino acid sequence with 95% or more sequence identity to the amino acid sequence of SEQ ID NO:
- 1 or a fragment of SEQ ID NO:
- 1 having 8 or more consecutive amino acids from the amino acid sequence of SEQ ID NO:
- 1,
- a polypeptide comprising an amino acid sequence with 95% or more sequence identity to the amino acid sequence of SEQ ID NO:
- 3 or a fragment of SEQ ID NO:
- 3 having 8 or more consecutive amino acids from the amino acid sequence of SEQ ID NO:
- 3,
- a polypeptide comprising an amino acid sequence with 95% or more sequence identity to the amino acid sequence of SEQ ID NO:
- 4 or a fragment of SEQ ID NO:
- 4 having 8 or more consecutive amino acids from the amino acid sequence of SEQ ID NO:
- 4, and
- a polypeptide comprising an amino acid sequence with 95% or more sequence identity to the amino acid sequence of SEQ ID NO:
- 6 or a fragment of SEQ ID NO:
- 6 having 8 or more consecutive amino acids from the amino acid sequence of SEQ ID NO:
- 6,
- wherein, the one or more polypeptides are immunogenic to one or more influenza strains in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the one or more isolated polypeptides are not a complete influenza virus protein.
Dependencies are inferred from the claim text.