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US 11,439,698 B2Granted
Toxoid preparation and uses thereof
AssigneeArytha Biosciences, LLC
InventorChe-Ming Jack Hu
Life of this patent
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Abstract
The present invention relates to toxoid preparations comprising a non-disrupted and/or a non-denatured toxin associated with a particulate vector that minimizes or precludes said toxin from inflicting damage at an action site of said toxin. The present invention also relates to immunogenic compositions or vaccines comprising the toxoid preparations, and the methods of using the toxoid preparations, immunogenic compositions or vaccines.
Claims7
An immunogenic composition comprising an effective amount of a liposome and an immunogenic adjuvant or immunopotentiator, and
- wherein said liposome comprises synthetic lipid bilayers and a pore-forming toxin absorbed in said synthetic lipid bilayers of said liposome, wherein:
- said synthetic lipid bilayers comprise sphingomyelin,
- said pore-forming toxin is alpha hemolysin of Staphylococcus aureus or an animal pore-forming toxin,
- said synthetic lipid bilayers further comprise a synthetic lipid that is selected from the group consisting of phosphotidylcholine, phosphotidylethanolamine, phosphatidylinositol and phosphotidylserine,
- said liposome has at least one dimension between about 1 nm and about 150 nm,
- said liposome does not comprise a solid inner core, and
- said pore-forming toxin substantially retains its natural structural integrity for eliciting an immune response to a natural pore-forming toxin.
4 more elements
Dependencies are inferred from the claim text.