Methods of treating spinal cord injury
AssigneeThe Cleveland Clinic Foundation
InventorsVinod Labhasetwar, Hayder H. Jaffer
Life of this patent
Estimating the term…
Abstract
The invention is directed to a method of treating a spinal cord injury, a neurodegenerative disease or a neuronal injury in an individual in need thereof comprising administering an effective amount of superoxide dismutase (SOD) and catalase to the individual, wherein the superoxide dismutase and the catalase are encapsulated in one or more nanoparticles that release the SOD and catalase upon administration. Another aspect of the invention is directed to compositions comprising superoxide dismutase (SOD) and catalase encapsulated in one or more nanoparticles.
Claims18
A method of treating a spinal cord injury in an individual in need thereof comprising:
- administering intravenously an effective amount of superoxide dismutase (SOD) and catalase to the individual in need thereof,
- wherein the superoxide dismutase and the catalase are encapsulated in one or more nanoparticles that localize at the spinal cord injury and release the SOD and the catalase upon administration,
- wherein the nanoparticles comprise poly (D,L-lactide co-glycolide) (PLGA) and polyvinyl alcohol;
- wherein the spinal cord injury is caused by a sudden fall, a vehicle accident, sports, or violence, and results in impact of mechanical force on the spinal cord that causes hemorrhage as a consequence of a primary injury and damages spinal cord tissue, and
- whereby the individual is treated for the spinal cord injury.
Dependencies are inferred from the claim text.