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US 11,439,685 B2Granted
Formulations for treating a fibrotic disease
AssigneesTrustees of Boston University, Beth Israel Deaconess Medical Center, Inc.
InventorsMark W. Grinstaff, William Blessing, Amanda Williamson, Jack Kirsch, Katherine Cook, Ara Nazarian, Edward K. Rodriguez
Life of this patent
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Abstract
The present invention provides formulations for the treatment of fibrotic diseases and disorders. In some embodiments, the formulation comprises a microparticle that includes an antifibrotic.
Claims16
A formulation comprising microparticles comprising an aliphatic polyester and an antifibrotic agent, wherein (i) said microparticles have a diameter of 1-100 μm;
- (ii) the antifibrotic agent is relaxin and is present in an amount that is 0.01-33% of total mass;
- (iii) said aliphatic polyester is of molecular weight 10,000-200,000 Daltons;
- or (iv) the microparticles further comprise a vinyl polymer.
Dependencies are inferred from the claim text.