Treating IgE-mediated allergic diseases

A method for treating atopic dermatitis or pruritus, the method comprising:

• (i) administering to a subject in need thereof a first dose of an antibody binding to a Cεmx domain of a membrane-bound IgE;
• and
• (ii) administering to the subject a second dose of the antibody;
• wherein the second dose is administered at least 8 weeks and up to 6 months after the first dose;
• wherein the antibody comprises a heavy chain variable region, which comprises (a) a heavy chain complementary determining region (CDR) 1, a heavy chain CDR2, and a heavy chain CDR3, and (b) a light chain variable region comprising a light chain CDR1, a light chain CDR2, and a light chain CDR3;
• and
• wherein:
• the heavy chain CDR1 comprises the amino acid sequence of residues 26-36 of SEQ ID NO:9;
• the heavy chain CDR2 comprises the amino acid sequence of residues 51-66 of SEQ ID NO:9,
• the heavy chain CDR3 comprises the amino acid sequence of residues 98-106 of SEQ ID NO:9,
• the light chain CDR1 comprises the amino acid sequence of residues 24-39 of SEQ ID NO:10,
• the light chain CDR2 comprises the amino acid sequence of residues 55-61 of SEQ ID NO:10;
• and
• the light chain CDR3 comprises the amino acid sequence of residues 94-102 of SEQ ID NO:10.