Loading patent…
AssigneesBiomed Valley Discoveries, Inc., The Johns Hopkins University
InventorsSaurabh Saha, Shibin Zhou, Bert Vogelstein, Kenneth W. Kinzler
Estimating the term…
The present invention provides, inter alia, methods for treating or ameliorating an effect of a solid tumor present in a human. These methods include administering intratumorally to the human a unit dose of C. novyi, preferably C. novyi NT, colony forming units (CFUs), which contains about 1×103-1×107 CFUs suspended in a pharmaceutically acceptable carrier or solution. Methods for debulking a solid tumor present in a human, methods for ablating a solid tumor present in a human, a method for microscopically precise excision of tumor cells in a human, methods for treating or ameliorating an effect of a solid tumor that has metastasized to one or more sites in a human, unit doses of C. novyi, preferably C. novyi NT, CFUs, and kits for treating or ameliorating an effect of a solid tumor present in a human are also provided.
A method for debulking or abalating a solid tumor present in a human comprising administering intratumorally to the human a unit dose of C. novyi colony forming units (CFUs) comprising 1×103-1×106 CFUs suspended in a pharmaceutically acceptable carrier or solution, wherein the C. novyi is effective to debulk or ablate the solid tumor without administration of additional anti-cancer agents.
A method for microscopically precise excision of tumor cells in a human comprising administering intratumorally to the human a unit dose of C. novyi NT colony forming units (CFUs) comprising 1×103-1×106 CFUs suspended in a pharmaceutically acceptable carrier or solution, wherein the C. novyi is effective for microscopically precise excision of the tumor cells without administration of additional anti-cancer agents.
A method for debulking or ablating a solid tumor that has metastasized to one or more sites in a human comprising administering intratumorally to the human a unit dose of C. novyi NT colony forming units (CFUs) comprising 1×103-1×106 CFUs suspended in a pharmaceutically acceptable carrier or solution, wherein the C. novyi is effective to debulk or ablate the solid tumor without administration of additional anti-cancer agents.
A method for debulking a solid tumor present in a human comprising administering intratumorally to the human a unit dose of C. novyi CFUs comprising 1×103-1×106 CFUs suspended in a pharmaceutically acceptable carrier or solution, wherein the C. novyi is effective to debulk the solid tumor without administration of additional anti-cancer agents.
A method for debulking a solid tumor present in a human comprising administering intratumorally to the human one to four cycles of a unit dose of C. novyi NT spores comprising 1×103-1×106 spores per cycle, each unit dose of C. novyi NT being suspended in a pharmaceutically acceptable carrier or solution, wherein the C. novyi is effective to debulk the solid tumor without administration of additional anti-cancer agents.
A method for debulking or ablating a solid tumor present in a human comprising administering intratumorally to the human one to four cycles of a unit dose of C. novyi NT spores comprising 1×103-1×106 spores per cycle, each unit dose of C. novyi NT spores being suspended in a pharmaceutically acceptable carrier or solution, wherein the C. novyi is effective to debulk or ablate the solid tumor without administration of additional anti-cancer agents.
A method for ablating a solid tumor present in a human comprising administering intratumorally to the human a unit dose of C. novyi CFUs comprising 1×103-1×106 CFUs suspended in a pharmaceutically acceptable carrier or solution, wherein the C. novyi is effective to ablate the solid tumor without administration of additional anti-cancer agents leaving a margin of normal tissue.
Dependencies are inferred from the claim text.