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US 11,439,664 B2Granted
Biologically relevant orthogonal cytokine/receptor pairs
AssigneesThe Board of Trustees of the Leland Stanford Junior University, University of Washington
InventorsKenan Christopher Garcia, Jonathan Sockolosky, David Baker, Chris King
Life of this patent
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Abstract
Engineered orthogonal cytokine receptor/ligand pairs, and methods of use thereof, are provided.
Claims52
A nucleic acid encoding a variant human CD122 polypeptide, the variant human CD122 polypeptide comprising amino acid substitutions at positions H133 and Y134, wherein numbering is made in reference to SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.