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AssigneesBoard of Regents, The University of Texas System, Dispersol Technologies, LLC
InventorsChris Brough, James W. McGinity, Dave A. Miller, James C. DiNunzio, Robert O. Williams, III
Estimating the term…
Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
A pharmaceutical composition comprising at least one active pharmaceutical ingredient (API) with at least one pharmaceutically acceptable excipient thermokinetically processed into a composite, wherein the at least one API comprises a thermally labile or poorly water-soluble API, and wherein the composite is processed at an average temperature that is at or below a glass transition temperature or a melting point of the at least one API.
Dependencies are inferred from the claim text.