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US 11,439,639 B2Granted
Pyrazine-containing compound
AssigneeCalcimedica, Inc.
InventorsGonul Velicelebi, Kenneth Stauderman, Michael Dunn, Jack Roos
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AssigneeCalcimedica, Inc.
InventorsGonul Velicelebi, Kenneth Stauderman, Michael Dunn, Jack Roos
Estimating the term…
Compositions and methods related to the amelioration of pancreatitis through the pharmaceutical manipulation of calcium signaling are disclosed. Such compositions and methods may be used to ameliorate symptoms of acute or chronic pancreatitis or to reduce the chance or severity of pancreatitis in an individual at risk of the condition. In other embodiments, disclosed herein are compositions and methods related to the amelioration of viral diseases through the pharmaceutical manipulation of calcium signaling. In further embodiments, disclosed herein are compositions and methods related to the amelioration of Th17-induced diseases through the pharmaceutical manipulation of calcium signaling.
A method for treating renal failure in a subject, comprising administering to the subject a therapeutically effective amount of a compound having a chemical name of N-[5-(6-chloro-2,2-difluorobenzo[d]1,3-dioxolen-5-yl)pyrazin-2-yl](2-fluoro-6-methylphenyl)carboxamide or a pharmaceutically acceptable sale thereof, wherein the subject has renal failure as a secondary manifestation of pancreatitis resulting from an inflammatory response.
A method for treating an autoimmune disease in a kidney in a subject, comprising administering to the subject a therapeutically effective amount of a compound having a chemical name of N-[5-(6-chloro-2,2-difluorobenzo[d]1,3-dioxolen-5-yl)pyrazin-2-y](2-fluoro-6-methylphenyl)carboxamide or a pharmaceutically acceptable sale thereof, wherein the autoimmune disease is Th17 induced.
Dependencies are inferred from the claim text.