Bupropion as a modulator of drug activity
AssigneeAntecip Bioventures II LLC
InventorHerriot Tabuteau
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Abstract
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
Claims22
A method of increasing dextromethorphan plasma levels in a human being, comprising orally administering, once a day or twice a day, a dosage form comprising bupropion and dextromethorphan to the human being, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, wherein the dosage form contains about 75 mg to about 150 mg of the bupropion and about 45 mg of the dextromethorphan and bupropion and dextromethorphan are the only therapeutically active agents to be administered, wherein the dosage form is orally administered for at least eight consecutive days, and wherein on the eighth day that the dosage form is orally administered, the human being has a Cmin of dextromethorphan that is at least about 40 ng/mL.
A method of increasing dextromethorphan plasma levels in a human being, comprising orally administering, once a day or twice a day, a dosage form comprising bupropion and dextromethorphan to the human being, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, wherein the dosage form contains about 75 mg to about 150 mg of the bupropion and about 45 mg of the dextromethorphan and bupropion and dextromethorphan are the only therapeutically active agents to be administered, wherein the dosage form is orally administered for at least eight consecutive days, and wherein on the eighth day that the dosage form is orally administered, the human being has a Cmin of dextromethorphan that is about 45 ng/mL.
A method of increasing dextromethorphan plasma levels in a human being, comprising orally administering, once a day or twice a day, a dosage form comprising bupropion and dextromethorphan to the human being, wherein the human being is an extensive metabolizer of dextromethorphan in need of treatment with dextromethorphan, wherein the dosage form contains about 75 mg to about 150 mg of the bupropion and about 45 mg of the dextromethorphan and bupropion and dextromethorphan are the only therapeutically active agents to be administered, wherein the dosage form is orally administered for at least eight consecutive days, and wherein on the eighth day that the dosage form is orally administered, the human being has a Cmin of dextromethorphan that is about 40 ng/mL to 119.3 ng/mL.
Dependencies are inferred from the claim text.