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US 11,439,633 B2Granted
Tetrahydroquinoline derivatives as P2X7 receptor antagonists
AssigneesRaQualia Pharma Inc., Asahi Kasei Pharma Corporation
InventorsYoshimasa Arano, Kazuki Toyoshima, Toshihiko Sone, Koki Matsubara
Life of this patent
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Abstract
The present invention relates to tetrahydroquinoline derivatives of the present invention or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the P2X7 receptor.
Claims2
A compound represented by the following formula (L-a) or a pharmaceutically acceptable salt thereof:
- wherein:
- R3 is independently selected from the group consisting of:
- (1) hydrogen, (2) halogen, (3) C1-6 alkyl and (4) —O—C1-6 alkyl;
- p is 0, 1, 2 or 3;
- when p is 2 or 3, each R3 is the same or different;
- R16 is selected from the group consisting of:
- (1) CN and (2) —CO2R18;
- R17 is selected from the group consisting of:
- (1) fluoro and (2) hydroxyl;
- or,
- R16 may form ═O with R17;
- R18 is selected from the group consisting of:
- (1) hydrogen and (2) C1-6 alkyl.
10 more elements
A compound represented by the following formula (L-b) or a pharmaceutically acceptable salt thereof:
- wherein:
- R3 is independently selected from the group consisting of:
- (1) hydrogen, (2) halogen, (3) C1-6 alkyl and (4) —O—C1-6 alkyl;
- p is 0, 1, 2 or 3;
- when p is 2 or 3, each R3 is the same or different;
- R4 is selected from the group consisting of:
- (1) hydrogen, (2) halogen and (3) hydroxyl.
4 more elements
Dependencies are inferred from the claim text.