Method of modulating ribonucleotide reductase
AssigneeCase Western Reserve University
InventorsChris G. Dealwis, Rajesh Viswanathan, Sarah E. Huff, William Harte
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Abstract
A method of modulating ribonucleotide reductase activity in a neoplastic cell includes administering to the cell an amount of a triazole or an oxadiazole ribonucleotide reductase modulator (RRmod), the amount being effective to inhibit neoplastic cell growth.
Claims12
A method of modulating ribonucleotide reductase activity in a neoplastic cell comprising administering to the cell an amount of a ribonucleotide reductase allosteric modulator (RRmod), the RRmod comprising an oxadiazole that is administered at an amount effective to inhibit neoplastic cell growth, wherein the RRmod is an oxadiazole having the following formula (IV):
- or pharmaceutically acceptable salts thereof:
- wherein R21 is selected from the group consisting of:
A method of treating a neoplastic disorder in a subject comprising:
- administering to neoplastic cells of the subject a therapeutically effective amount of a pharmaceutical composition, the composition comprising a reductase allosteric modulator (RRmod), the RRmod including an oxadiazole that is administered at an amount effective to inhibit neoplastic cell growth, wherein the RRmod is an oxadiazole having the following formula (IV):
- or pharmaceutically acceptable salts thereof:
- wherein R21 is selected from the group consisting of:
Dependencies are inferred from the claim text.