Lipoxin and lipoxin analogue mediated neuroprotection and treatments
AssigneesUniversity Health Network, The Regents of the University of California
InventorsJeremy M. Sivak, Izhar Livne-Bar, John G. Flanagan, Karsten Gronert, Jessica Wei
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Abstract
Methods and compositions for inhibiting or preventing neurodegeneration, specifically hippocampal, cortical, and/or retinal ganglion cell neurons (RGC), and degeneration and/or cell loss or treating related disorders and diseases comprising administering to a subject an effective amount of one or more lipoxin compounds and/or lipoxin analogues such that degeneration and/or cell loss of neurons is inhibited or prevented.
Claims17
A method for providing neuroprotection from and/or treating a chronic neurodegenerative retinal or brain disorder or condition comprising administering to a subject afflicted with said disorder or condition an effective amount of lipoxin B4 (LXB4) and/or an analog thereof, wherein the chronic retinal or brain neurodegenerative disorder or condition is selected from the group consisting of glaucoma, retinal ischemia, diabetic retinopathy, diabetic macular edema, age related macular degeneration, retinitis pigmentosa, Alzheimer's disease, multiple sclerosis, Parkinson's disease, and amyotrophic lateral sclerosis.
Dependencies are inferred from the claim text.