Fish egg extracts, omega-3 lipid-based compositions and uses thereof

A homogenous solid composition consisting of:

• about 250 mg to about 5000 mg of omega-3 fatty acid ethyl esters in solid form, wherein said omega-3 fatty acid ethyl esters are in the form of microencapsulated omega-3 fatty acids ethyl esters, and wherein the docosahexaenoic acid (DHA) ethyl ester/eicosapentaenoic acid (EPA) ethyl ester ratio in said omega-3 fatty acid ethyl esters is from 1/4 to 4/1;
• about 10 mg to about 100 mg of vitamin B6;
• about 75 mg to about 500 mg of magnesium in the form of a pharmaceutically acceptable salt;
• at least 3.5 mg of zinc in the form of a pharmaceutically acceptable salt;
• optionally at least 100 μg of copper in the form of picolinate, glycinate, orotate or gluconate;
• optionally about 20 mg to about 200 mg of a sediment obtained by a method comprising:
• (a) grinding fish roe or eggs in the presence of an antioxidant;
• (b) submitting said fish roe or eggs to an osmotic shock at a temperature of less than about 10° C. for at least 20 minutes to obtain a lysed fish roe or egg mixture;
• (c) sedimenting the mixture obtained in (b) at a temperature of less than about 10° C., thereby obtaining a supernatant fraction enriched in vitellogenin and a sediment fraction enriched in phospholipids;
• (d) separating the supernatant fraction and sediment fraction by filtration or decantation;
• and
• (e) drying the sediment and coagulum at a temperature of about −30° C. to about 50° C.;
• optionally about 50 mg to about 500 mg of gamma-linolenic acid (GLA);
• optionally about 0.1 mg to about 1 mg of folic acid;
• and
• one or more pharmaceutically acceptable excipients.