US 11,439,609 B2 · Nitric oxide releasing PLGA microspheres for biomedical applications

Abstract

A polymeric composition includes poly(lactide-co-glycolide) (PLGA) microspheres; and at least one of a discrete RSNO adduct or a polymeric RSNO encapsulated within the microspheres, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymeric composition exhibits stability under dry conditions at 37° C. and prolonged and controllable NO release rates, when exposed to light capable of photolyzing an RSNO bond, or when exposed to moisture, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct.

Claims17

Dependent claims

A polymeric composition, consisting of:

poly(lactide-co-glycolide) microspheres or poly(lactic-co-glycolic acid) microspheres;
and
S-nitroso-N-acetylpenicillamine (SNAP) or a biodegradable polymer possessing an appended SNAP encapsulated within the poly(lactide-co-glycolide) microspheres or poly(lactic-co-glycolic acid) microspheres by a solid-in-oil-in-water emulsion and solvent evaporation method, wherein the SNAP or the biodegradable polymer possessing the appended SNAP is capable of spontaneously releasing nitric oxide (NO) when exposed to light capable of photolyzing an S-nitrosothiol (RSNO) bond or when exposed to moisture;
the polymeric composition to exhibit stability under dry conditions at 37° C., and prolonged and controllable NO release rates, when exposed to the light or the moisture, for a predetermined amount of time.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

15/735,122Filed 10 Jun 2016 · us provisional application

Priority

11 Jun 2015

Published

US 2019/0307710 A110 Oct 2019

Granted

13 Sep 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61K 31/19
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids: carboxylic acids, e.g. valproic acid
A61K 9/0014
Galenical forms characterised by the site of application: skin, i.e. galenical aspects of topical compositions
A61K 9/0024
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in…
A61K 9/06
Medicinal preparations characterised by special physical form: ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Nitric oxide releasing PLGA microspheres for biomedical applications

Life of this patent

Nitric oxide releasing PLGA microspheres for biomedical applications

Life of this patent

Abstract

Claims17