Formulations of (R)-2-amino-3-phenylpropyl carbamate

A solid pharmaceutical formulation for oral delivery of (R)-2-amino-3-phenylpropyl carbamate (APC) consisting of

• i) a pharmaceutically acceptable salt of APC containing 150 mg of APC;
• ii) a binder in an amount of about 1-5% by weight of the formulation;
• iii) a lubricant in an amount of about 0.1-2% by weight of the formulation;
• and
• iv) an optional coating;
• wherein the formulation releases at least 85% of the pharmaceutically acceptable salt of APC in less than 15 minutes after oral administration of the formulation to a subject;
• and wherein the formulation exhibits substantially identical dissolution rates of the pharmaceutically acceptable salt of APC at pH 1.2, pH 4.5, and pH 6.8;
• wherein the binder is selected from hydroxypropyl cellulose, hydroxypropyl methylcellulose, and povidone:
• wherein the lubricant is selected from magnesium stearate, calcium stearate, and sodium stearyl fumarate, and sodium stearyl fumarate.