Injectable implants
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsMichael Friedman, David Kirmayer, Rami Mosheiff, Jacob Rachmilewitz, Amal Khoury, Doron Steinberg
Life of this patent
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Abstract
Provided herein injectable implant compositions useful for acceleration of bone fracture healing, treatment of dental or oral pathologies, and controlled drug delivery.
Claims23
An injectable polymer-based implant composition comprising an ammonio-methacrylate copolymer said copolymer being dissolved in an injectable solvent, an additive which is a water-soluble salt, and optionally a pharmaceutically active agent, wherein upon contact with an aqueous medium polymer(s) of the implant composition form a stable solidified residue, and wherein said injectable solvent is soluble in or miscible with water and is an aprotic solvent, wherein said additive is a calcium-containing salt, and water is present in an amount between 0.5 and 20 weight percent.
Method of accelerating a bone fracture healing in a patient in need thereof by administering perifracturally an injectable polymer-based implant composition comprising an ammonio-methacrylate copolymer, said copolymer being dissolved in an injectable solvent, an additive which is a water-soluble salt, and optionally a bone active agent, wherein upon contact with an aqueous medium polymer(s) of the implant form a stable solidified residue, and wherein said injectable solvent is soluble in or miscible with water and is an aprotic solvent, wherein said additive is a calcium-containing salt, and water is present in an amount between 0.5 and 20 weight percent.
Method of treatment of a dental or an oral pathology in a patient in need thereof by administering to said patient an injectable polymer-based implant composition comprising an ammonio-methacrylate copolymer, said copolymer being dissolved in an injectable solvent, an additive which is a water-soluble salt, and a pharmaceutically active agent, wherein upon contact with an aqueous medium polymer(s) of the implant form a stable solidified residue, and wherein said injectable solvent is soluble in or miscible with water and is an aprotic solvent, wherein said additive is a calcium-containing salt, and
- water is present in an amount between 0.5 and 20 weight percent.
Method of treatment of a pathology in a patient in need thereof by administering to said patient intramuscularly, subcutaneously or intraperitoneally an injectable polymer-based implant composition comprising an ammonio-methacrylate copolymer, said copolymer being dissolved in an injectable solvent, an additive which is a water-soluble salt, and a pharmaceutically active agent, wherein upon contact with an aqueous medium polymer(s) of the implant form a stable solidified residue, and wherein said injectable solvent is soluble in or miscible with water and is an aprotic solvent wherein said additive is a calcium-containing salt, and water is present in an amount between 0.5 and 20 weight percent.
Dependencies are inferred from the claim text.