Intratumour injection formulation
AssigneeUS Nano Food & Drug, Inc
InventorsHing Sang Pui, Yip Shu Pui
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Abstract
Formulations and uses of the formulations for treating a malignant mass in a mammal by administering an injectable formulation comprising a therapeutically effective amount of a chemotherapeutic agent dissolved or suspended in a biocompatible carrier directly into the malignant mass are disclosed. In certain preferred embodiments, the injectable formulation is a taxane (e.g. paclitaxel), a podophyllotoxin derivative (e.g., etoposide), or a camptothecin derivative (e.g., hydroxycamptothecin).
Claims23
A method of treating a malignant mass in a mammal, comprising administering an injectable formulation suitable for intratumor administration directly into the malignant mass, the injectable formulation consisting of a therapeutically effective amount of a water insoluble chemotherapeutic agent selected from a taxane, a podophyllotoxin derivative, a camptothecin derivative, and mixtures thereof dissolved or suspended in a pharmaceutically acceptable biocompatible carrier comprising a medium chain triglyceride or a pharmaceutically acceptable vegetable oil, and an optional solvent which when included consists of a non-aqueous solvent, wherein the injectable formulation is a colorless and transparent stable non-aqueous solution that does not include cholesterol, a phospholipid, a protein, or surfactant.
A stable intratumor injectable formulation of a water insoluble chemotherapeutic agent, consisting of a therapeutically effective amount of a chemotherapeutic agent selected from a taxane, a podophyllotoxin derivative, a camptothecin derivative, and mixtures thereof in a pharmaceutically acceptable biocompatible carrier for injection comprising a medium chain triglyceride or a pharmaceutically acceptable vegetable oil, and an optional solvent which when included consists of a non-aqueous solvent, wherein the injectable formulation is stable and suitable for intratumor administration as a solution and is a colorless and transparent non-aqueous solution that does not include cholesterol, a phospholipid, a protein, or surfactant.
An intratumor injectable formulation kit, comprising a first vial containing a powdered water insoluble chemotherapeutic agent selected from a taxane, a podophyllotoxin derivative, a camptothecin derivative, and mixtures thereof, and a second vial containing the pharmaceutically acceptable excipients needed to deliver the chemotherapeutic agent to a tumor, the pharmaceutically acceptable excipients consisting of a pharmaceutically acceptable biocompatible carrier comprising a medium chain triglyceride or a pharmaceutically acceptable vegetable oil, and an optional solvent which when included consists of a non-aqueous solvent, wherein the injectable formulation is suitable for intratumor administration as a solution that is stable, colorless, transparent and non-aqueous and does not include cholesterol, a phospholipid, a protein, or surfactant.
Dependencies are inferred from the claim text.