Electrical energy ablation systems, devices and methods for the treatment of tissue

A system for ablating tissue with electrical energy comprising:

• an ablation device comprising:
• an elongate shaft with a proximal portion and a distal portion;
• a radially expandable element attached to the elongate shaft distal portion;
• and
• an ablation element mounted to the radially expandable element, the ablation element comprising a circumferential array of conductors, wherein the ablation element is constructed and arranged to deliver electrical energy to target tissue;
• and
• an energy delivery unit constructed and arranged to deliver electrical energy to the ablation element of the ablation device, wherein the target tissue comprises duodenal mucosal tissue;
• and
• wherein the energy delivery unit is configured to deliver the electrical energy to the ablation element to cause the target tissue to increase in temperature to a setpoint temperature between 60° C. and 90° C., wherein the system is configured to maintain the set point temperature for at least 5 seconds and to deliver energy to the ablation element with an average power density that is less than 20 watts per cm2;
• and
• wherein the system is configured to deliver the electrical energy to cause non-desiccating ablation of the target tissue by avoiding creation of steam.