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US 11,439,326 B2Granted
Analyte monitoring: stabilizer for subcutaneous glucose sensor with incorporated antiglycolytic agent
AssigneeAbbott Diabetes Care Inc.
InventorsTianmei Ouyang, Zenghe Liu, Hyun Cho, Benjamin J. Feldman
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Abstract
An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.
Claims23
A glucose sensor comprising:
- a) a working electrode comprising a sensing layer disposed thereon, the sensing layer comprising a glucose responsive enzyme;
- b) a counter electrode;
- and
- c) a coating comprising an active agent and a chelating agent, the coating positioned proximate to the working electrode, wherein the active agent comprises an antiglycolytic agent, and wherein the chelating agent stabilizes the active agent.
1 more element
A glucose sensor comprising:
- a) a working electrode comprising a sensing layer disposed thereon, the sensing layer comprising a glucose responsive enzyme;
- b) a counter electrode;
- and
- c) a membrane disposed over at least a portion of the sensing layer, the membrane comprising an active agent and a chelating agent, wherein the active agent comprises an antiglycolytic agent, and wherein the chelating agent stabilizes the active agent.
1 more element
A glucose sensor comprising:
- a) a working electrode comprising a sensing layer disposed thereon, the sensing layer comprising a glucose responsive enzyme;
- b) a counter electrode;
- and
- c) an active agent and a chelating agent positioned proximate to the working electrode, wherein the active agent comprises an antiglycolytic agent, and wherein the active agent is chemically bonded to the chelating agent.
1 more element
A glucose sensor comprising:
- a) a working electrode comprising a sensing layer disposed thereon, the sensing layer comprising a glucose responsive enzyme;
- b) a counter electrode;
- and
- c) a coating comprising an active agent and a chelating agent, the coating positioned proximate to the working electrode, wherein the active agent comprises an antiglycolytic agent or precursor thereof, and wherein the chelating agent stabilizes the active agent.
1 more element
A glucose sensor comprising:
- a) a working electrode comprising a sensing layer disposed thereon, the sensing layer comprising a glucose responsive enzyme;
- b) a counter electrode;
- and
- c) a membrane disposed over at least a portion of the sensing layer, the membrane comprising an active agent and a chelating agent, wherein the active agent comprises an antiglycolytic agent or precursor thereof, and wherein the chelating agent stabilizes the active agent.
1 more element
A glucose sensor comprising:
- a) a working electrode comprising a sensing layer disposed thereon, the sensing layer comprising a glucose responsive enzyme;
- b) a counter electrode;
- and
- c) an active agent and a chelating agent positioned proximate to the working electrode, wherein the active agent comprises an antiglycolytic agent or precursor thereof, and wherein the active agent is chemically bonded to the chelating agent.
1 more element
Dependencies are inferred from the claim text.