Implantable resonator system for deep-tissue EPR oximetry with reduced noise

A resonator system operable for use in electron paramagnetic resonance (EPR) oximetry, the system comprising:

• a resonator having an implantable end, a transmission line, and an external end, the implantable end comprising a plurality of sensing loops comprising a plurality of sensors and the external end comprising a coupling loop operably connected to the plurality of sensing loops via the transmission line;
• and
• a spring-loaded clamping mechanism operable to couple the coupling loop to a resonator loop, the clamping mechanism comprising:
• the resonator loop operably connected to a spectrometer and operable to inductively connect to the coupling loop;
• a recessed circular pocket operable to receive the coupling loop;
• and
• one or more raised alignment guides to align the coupling loop and the resonator loop parallel to each other,
• wherein the implantable end is suitable for implantation within a tissue of a subject and the external end is operable to be located externally from the subject, and
• wherein the system produces a signal to noise ratio of greater than 1 when the resonator loop is inductively connected to the coupling loop.