Dialysis systems, devices, and methods

A treatment device system, comprising:

• a treatment machine for generating a custom dialysis solution and including at least one fluid conveyor, the treatment machine comprising a controller, the controller comprising a first memory, the treatment machine configured to produce the custom dialysis solution by causing the at least one fluid conveyor to mix purified water and at least one concentrate;
• a user interface operably connected to the treatment machine, the user interface configured to receive operator inputs;
• a water purifier in fluid communication with and providing the purified water to the treatment machine, the water purifier including an internal central controller to control preparation of the purified water, the internal central controller comprising a second memory;
• a server communicatively coupled with the treatment machine;
• and
• a wired or wireless control line providing two way communication between the controller of the treatment machine and the internal central controller of the water purifier, wherein the internal central controller of the water purifier transmits sensor signals via the control line to the controller of the treatment machine, wherein the controller of the treatment machine forwards data related to the sensor signals to the server.