System for extended storage of red blood cells and methods of use
AssigneeHemanext Inc.
InventorsTatsuro Yoshida, Paul Vernucci
Life of this patent
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Abstract
A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.
Claims19
A method of preparing red blood cells for transfusion in the treatment of sickle cell in a subject in need thereof comprising:
- obtaining whole blood;
- separating red blood cells from said whole blood to form packed red blood cells;
- depleting oxygen and carbon dioxide from said packed red blood cells prior to storage to prepare depleted packed red blood cells;
- and
- storing said depleted packed red blood cells in an anaerobic storage bag comprising an outer bag having a barrier film that is impermeable to oxygen and carbon dioxide, and an inner bag in contact with said red blood cells, wherein said depleted packed red blood cells are maintained in an anaerobic condition, to form stored depleted red blood cells.
A method of preparing red blood cells for transfusion in the treatment of sickle cell in a subject in need thereof comprising:
- obtaining previously stored oxygen and carbon dioxide depleted packed red blood cells wherein said depleted packed red blood cells were depleted prior to storage and said storage was in an anaerobic storage bag comprising an outer bag having a barrier film that is impermeable to oxygen and carbon dioxide, and an inner bag in contact with said depleted packed red blood cells;
- oxygenating said previously stored depleted red blood cells creating oxygenated red blood cells;
- and
- transfusing said red blood cells into a subject in need thereof.
Dependencies are inferred from the claim text.