Bone repair compositions
AssigneeBonus Therapeutics Ltd.
InventorShai Meretzki
Life of this patent
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Abstract
A composition including, (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid, is provided. Moreover, a kit which includes: a syringe, a mineral particle covered with endothelial cells and mesenchymal cells organized in 2 or more cell layers attached to the mineral particle, and hyaluronic acid, is also provided. Last, a method for filling a gap in a bone of a subject in need thereof, including contacting the gap with a composition of: (a) a mineral particle, (b) endothelial cells and mesenchymal cells, and (3) hyaluronic acid is provided.
Claims15
A composition comprising (a) a mineral particle having a diameter in the range of 50 microns to 2,000 microns and endothelial cells and mesenchymal cells organized in 2 or more cell layers, wherein said 2 or more cell layers are attached to said mineral particle, wherein at least 1×103 endothelial and mesenchymal cells occupy 1 mg of said mineral particle, and (b) an injectable medium comprising hyaluronic acid and liquid solution, wherein said hyaluronic acid is present in an amount of 0.05% to 5% by weight of said injectable medium, said liquid solution comprises a physiological salt buffer, wherein said (a) is dispersed in said (b).
Dependencies are inferred from the claim text.