Hydratable and flowable implantable compositions and methods of making and using them
AssigneeWarsaw Orthopedic, Inc.
InventorsIan Dunkley, Gretchen Selders
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Abstract
Implantable bone compositions are provided. The implantable compositions comprise hydratable bone putties. The hydratable bone putties comprise porous ceramic granules having an average diameter from about 50 μm to 800 μm. The porous ceramic granules comprise hydroxyapatite and beta-tricalcium phosphate. The implantable bone compositions further include collagen carriers. In some embodiments, the hydratable bone putty can be hydrated to form a non-settable flowable cohesive cement or gel. Methods of making and using the implantable compositions are also provided.
Claims20
An implantable composition comprising porous ceramic granules, the porous ceramic granules having an average diameter from about 50 μm to 800 μm and comprising hydroxyapatite and beta-tricalcium phosphate;
- and a collagen carrier, wherein the porous ceramic granules have a microporosity, and the diameter of each of the micropores is from about 0.01 to about 10 microns, and each of the porous ceramic granules has a Brunauer-Emmett-Teller (BET) surface area from about 0.2 to about 10 m2/g, wherein the composition comprises from about 77 to about 93 wt. % porous ceramic granules and from about 7 to about 23 wt. % of the collagen carrier, and the composition has a texture value of from about 200 to about 1000.
A composition comprising porous ceramic granules, the porous ceramic granules having an average diameter from about 50 μm to 800 μm and comprising hydroxyapatite and beta-tricalcium phosphate;
- and a collagen carrier comprising bovine type I collagen, wherein the porous ceramic granules have a microporosity, and the diameter of each of the micropores is from about 0.01 to about 10 microns, and each of the porous ceramic granules has a Brunauer-Emmett-Teller (BET) surface area from about 0.2 to about 10 m2/g, wherein the composition comprises from about 77 to about 93 wt. % porous ceramic granules and from about 7 to about 23 wt. % of the collagen carrier, and the composition has a texture value of from about 200 to about 1000.
Dependencies are inferred from the claim text.