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US 11,433,146 B2Granted
Formulations for small intestinal delivery of RSV and norovirus antigens
AssigneeVaxart, Inc.
InventorsGeorge Trager, Sean Tucker, Leesun Kim, Ciaran Scallan
Life of this patent
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Abstract
Provided herein are compositions and methods for generating an immunogenic response in humans. Further provided are methods for designing such compositions, e.g., for vaccines.
Claims16
An immunogenic composition for eliciting serum IgG and intestinal secretory IgA immune responses in a human, the composition comprising:
- (i) an E1/E3-deleted replication-incompetent serotype 5 adenoviral vector comprising a nucleic acid sequence encoding a viral protein 1 (VP1) polypeptide of norovirus and a nucleic acid sequence encoding a dsRNA adjuvant, encompassed by (ii) an enteric coating having a threshold pH of 5.8-7.0 that directs delivery and release of the adenoviral vector to the ileum of the human;
- wherein the nucleic acid encoding the VP1 polypeptide has at least 90% identity to SEQ ID NO:3 or at least 90% identity to SEQ ID NO:1.
An expression vector comprising a heterologous nucleic acid encoding a viral protein 1 (VP1) of norovirus, wherein the heterologous nucleic acid comprises a nucleic acid sequence having at least 90% identity to SEQ ID NO:3 or SEQ ID NO:1.
Dependencies are inferred from the claim text.