Anti-B7-H4 antibody
AssigneeShizuoka Prefecture
InventorsYasuto Akiyama, Akira Iizuka
Life of this patent
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AssigneeShizuoka Prefecture
InventorsYasuto Akiyama, Akira Iizuka
Estimating the term…
An object is to produce a new anti-B7-H4 antibody having high specificity and affinity and provide a composition for treating cancer making use thereof. A monoclonal antibody that specifically binds to an extracellular domain protein of a human B7-H4 protein is newly produced and an “anti-B7-H4 antibody-effector cell complex” in which the monoclonal antibody and an effector cell are bound in order to enhance the antibody-dependent cellular cytotoxicity of the monoclonal antibody or a bispecific antibody comprising an antigen recognition region of the monoclonal antibody and an effector cell antigen recognition region is further produced and used as a composition for treating cancer.
An antibody that specifically binds to an extracellular domain of a human B7-H4 protein comprising amino acid residues Leu25 to Ser259 of SEQ ID NO:
A bispecific antibody comprising any one of following regions (a) to (c) that specifically bind to an extracellular domain of a human B7-H4 protein composed of a region from Leu25 to Ser259 of SEQ ID NO:
Dependencies are inferred from the claim text.