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US 11,433,137 B2Granted
Compounds for treating cancer
AssigneeBicycleRD Limited
InventorsGavin Bennett, Daniel Paul Teufel
Life of this patent
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Abstract
The present invention provides compounds, compositions thereof, and methods of using the same.
Claims28
A method for treating cancer in a patient in need thereof, comprising administering to said patient a compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- Bicycle is a polypeptide which is covalently bound to a molecular scaffold such that two or more peptide loops are subtended between attachment points to the scaffold, wherein the polypeptide is:
- C-X-U/O-X-X-G-C-E-D-F-Y-X-X-C- (SEQ ID NO:
- 1) wherein X represents any amino acid residue;
- U represents a polar, uncharged amino acid residue selected from N, C, Q, M, S and T;
- and O represents a non-polar aliphatic amino acid residue selected from G, A, I, L, P and V;
- or
- C(D-Ala)NE(1Nal)(D-Ala)CEDFYD(tBuGly)C- (SEQ ID NO:
- 5) wherein D-Ala represents D-alanine;
- 1Nal represents 1-naphthylalanine;
- and tBuGly represents tert-butylglycine;
- Spacer is
- AA1-AA2 is a bivalent moiety comprising at least one citrulline moiety that connects the Spacer moiety with the Linker moiety, wherein each of AA1 and AA2 is an independently selected natural or unnatural amino acid moiety;
- Linker is a bivalent spacer moiety that connects AA1-AA2 moiety with the Toxin moiety;
- and
- Toxin is a chemotherapeutic agent.
13 more elements
A method for treating cancer in a patient in need thereof, comprising administering to said patient a compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- Bicycle is a polypeptide which is covalently bound to a molecular scaffold such that two or more peptide loops are subtended between attachment points to the scaffold;
- Spacer is a bivalent moiety that connects the Bicycle moiety with the AA1-AA2 moiety, which is selected from
- AA1-AA2 is a bivalent moiety comprising at least one citrulline moiety that connects the Spacer moiety with the Linker moiety, wherein each of AA1 and AA2 is an independently selected natural or unnatural amino acid moiety;
- Linker is a bivalent spacer moiety that connects AA1-AA2 moiety with the Toxin moiety;
- and
- Toxin is a chemotherapeutic agent.
4 more elements
Dependencies are inferred from the claim text.