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US 11,433,135 B2Granted
High capacity diketopiperazine microparticles and methods
AssigneeMannKind Corporation
InventorsMarshall Grant, Paul Menkin, Grayson W. Stowell
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Abstract
Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
Claims16
A drug deliverable agent for pulmonary inhalation for treating disease, the drug deliverable agent comprising:
- diketopiperazine microparticles;
- wherein said diketopiperazine microparticles comprise
- a specific surface area greater than about 70 m2/g,
- a mass-weighted average particle size of about 33,000 to about 216,000 voxels measured by X-ray tomography for particle size measuring about 0.5 μm to about 4 μm in geometric diameter,
- a plurality of structural domains having one or more cores surrounded by layers of a porous crystalline material, and
- a concentration of an active ingredient, or analog thereof, of about 18% to about 25% by weight of said microparticle.
3 more elements
Dependencies are inferred from the claim text.