Aqueous formulation of erythropoiesis stimulating protein stabilised by antioxidants for parenteral administration

An aqueous formulation comprising (i) an IgG1 antibody and (ii) a concentration of an antioxidant wherein the antioxidant is p-hydroxybenzoic acid, sulisobenzone, vanillic acid, or syringic acid, or a pharmaceutically acceptable salt or ester thereof, or mixtures thereof;

• when the antioxidant is sulisobenzone, the antioxidant is present in the aqueous formulation at a concentration of about 5 mM,
• when the antioxidant is p-hydroxybenzoic acid, vanillic acid or syringic acid, the antioxidant is present in the aqueous formulation at a concentration of about 20 mM,
• wherein the antibody exhibits less than about 10% degradation as determined by exposure for about 3 hours to a 8 watt mid UV lamp having a spectral distribution from 270 nm to 360 nm with a maximum energy emission of about 302 nm and
• wherein the formulation is suitable for parenteral administration.