Adoptive cell therapy using spherical nucleic acids (SNAs)
AssigneeNorthwestern University
InventorsChad A. Mirkin, Andrew Lee, Bin Zhang, Donye Dominguez
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Abstract
The disclosure is related to compositions comprising a cell and a spherical nucleic acid (SNA) comprising a nanoparticle, an oligonucleotide on the surface of the nanoparticle, and an antigen; and to methods for production of such compositions and their applications, including but not limited to adoptive cell therapy.
Claims32
A method of treating lung cancer or melanoma in an individual comprising administering to the individual a composition comprising a pharmaceutically acceptable carrier and a T cell having a spherical nucleic acid (SNA) contained therein, wherein the T cell is obtained from an individual and the SNA comprises a nanoparticle, an immunostimulatory oligonucleotide comprising a sequence that is a toll-like receptor (TLR) agonist on the surface of the nanoparticle, and a tumor associated antigen.
A method of producing an immune response to lung cancer or melanoma in an individual, comprising administering to the individual an effective amount of a composition comprising a pharmaceutically acceptable carrier and a T cell having a spherical nucleic acid (SNA) contained therein, wherein the T cell is obtained from an individual and the SNA comprises a nanoparticle, an immunostimulatory oligonucleotide comprising a sequence that is a toll-like receptor (TLR) agonist on the surface of the nanoparticle, and a tumor associated antigen, thereby producing an immune response to cancer in the individual.
Dependencies are inferred from the claim text.