Sustained release cowpea mosaic virus or virus-like particle therapeutic constructs for the treatment of cancer

A method of treating cancer in a subject in need thereof, the method comprising:

• administering in situ to cancer cells of the subject a nanoparticle construct, the nanoparticle construct comprising:
• a plurality of cowpea mosaic virus or virus-like particles and
• a plurality of G4 dendrimers having a different surface charge than the cowpea mosaic virus or virus-like particles electrostatically coupled to the cowpea mosaic virus or virus-like particles, the nanoparticle construct upon in situ delivery to the subject providing a sustained release of the cowpea mosaic virus or virus-like particles and/or nanoparticles to the cancer cells, wherein the cancer is selected from the group consisting of melanoma, breast cancer, colon cancer, lung cancer, and ovarian cancer.