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US 11,433,118 B2Granted
Long-acting VEGF inhibitors for intraocular neovascularization
AssigneeThe Regents of the University of California
InventorNapoleone Ferrara
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Abstract
Compositions and methods for treating a VEGF-related ophthalmic disorder in a subject in need comprising, administering intravitreally to the subject a therapeutically effective amount of an anti-VEGF agent, comprising a VEGF binding portion operatively linked to a Fc-IgG, wherein the VEGF binding portion comprises at least one VEGF binding domain that is an IgG-like domain 2 of VEGFR-1.
Claims6
A method of treating a VEGF related condition in an eye of a subject comprising:
- administering to the eye an anti-VEGF agent consisting of the amino acid residues 27 to 459 of SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.