Anti-cancer oncolytic virus combination therapies and elite responder selection platforms

A method of treating cancer comprising:

• orally administering to a subject an effective amount of about 109 to 1011 cfu of gut microbiota of the genus Bifidobacterium;
• and
• from about one week to two months after the gut microbiota are administered, intravenously or intratumorally administering to the subject an effective amount of about 105 to 1010 pfu of an oncolytic ORF virus having anticancer activity and that selectively targets tumor cells;
• wherein the gut microbiota pre-conditions the subject's immune system to antitumor responses and augments the anticancer activity of the oncolytic ORF virus, and
• wherein a platform is created to identify potential elite responders to the oncolytic ORF virus treatment based on an abundance of the subject's particular gut microbiota.