Bacterial compositions
AssigneeMelaleuca, Inc.
InventorSubhendu Nayak
Life of this patent
Estimating the term…
Abstract
This document provides bacterial compositions. For example, bacterial compositions having a combination of different bacterial strains formulated in a manner to maintain the stability of the bacteria are provided.
Claims29
A bacterial composition comprising Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus paracasei, and Bifidobacterium lactis,
- wherein said bacterial composition is effective to release said Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus paracasei, and Bifidobacterium lactis, within an intestine of a mammal following oral administration to said mammal;
- wherein said composition comprises microcrystalline cellulose (MCC) and has a water activity of about 0.125 to about 0.3;
- and
- wherein said bacterial composition comprises a uniform silicon dioxide coating that reduces moisture absorption by said Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus paracasei, and Bifidobacterium lactis prior to oral administration to said mammal.
A method for making a bacterial composition, wherein said method comprises:
- (a) coating lyophilized bacteria to form coated lyophilized bacteria having a uniform silicon dioxide coating, wherein the bacteria comprise Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus paracasei, and Bifidobacterium lactis,
- (b) adding MCC having a water activity of less than 0.3 and fructooligosaccharides to said coated lyophilized bacteria to form a mixture, wherein said mixture has a water activity of about 0.125 to about 0.3, and
- (c) encapsulating said mixture into a capsule, thereby forming said bacterial composition, wherein said capsule is effective to release said Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus paracasei, and Bifidobacterium lactis within an intestine of a mammal following oral administration to said mammal.
A bacterial composition comprising lyophilized bacteria having a uniform silicon dioxide coating, wherein said lyophilized bacteria is a mixture of lyophilized Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus paracasei, and Bifidobacterium lactis;
- wherein said bacterial composition is in the form of a capsule effective to release said Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus paracasei, and Bifidobacterium lactis within an intestine of a mammal following oral administration to said mammal;
- wherein said composition has a water activity of about 0.125 to about 0.3, and
- wherein said the bacterial composition comprises MCC.
A bacterial composition comprising:
- (a) lyophilized Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus paracasei, and Bifidobacterium lactis,
- (b) fructooligosaccharides, and
- (c) MCC in an amount of about 300 mg to about 700 mg for every gram of the composition;
- wherein said bacterial composition is in the form of a capsule effective to, following oral administration to a mammal, release said Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus paracasei, and Bifidobacterium lactis within an intestine of said mammal when the composition reaches a location of the intestine having a pH above about 6.8;
- wherein said composition has a water activity of about 0.13 to about 0.3;
- and
- wherein said bacterial composition comprises a uniform silicon dioxide coating that reduces moisture absorption by said Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus paracasei, and Bifidobacterium lactis prior to oral administration to said mammal.
Dependencies are inferred from the claim text.