Compositions and methods for treating Parkinson's disease (PD) and related disorders
AssigneeFinch Therapeutics Holdings LLC
InventorThomas J. Borody
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Abstract
The present disclosure is in the field of pharmaceutical compositions suitable for the treatment of diseases in mammals. The disclosure provides novel compositions comprising non-pathogenic fecal microbes or a sterile fecal filtrate for treating Parkinson's disease and related diseases. The disclosure also provides methods for treating a subject with the compositions disclosed herein.
Claims24
A method for treating Parkinson's disease (PD) in a human subject in need thereof, the method comprising orally administering to the human subject one or more compositions comprising (i) a pharmaceutically active induction dose of a therapeutic composition comprising a fecal bacterial preparation comprising a community of live non-pathogenic fecal bacteria from a stool or portion thereof of a healthy human donor, and (ii) a second active agent, wherein the subject is further administered a maintenance dose of the therapeutic composition, wherein the maintenance dose is lower than the induction dose, wherein at least two doses of the therapeutic composition are administered to the subject over a two-week period, and
- wherein the human subject experiences an improvement in at least one symptom selected from the group consisting of tremor, slowed movement, rigid muscles, impaired posture and balance, loss of automatic movements, speech changes, and writing changes within 15 weeks after initiating treatment.
Dependencies are inferred from the claim text.