Compositions and methods for treatment of cancers harboring an H3K27M mutation
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsMichelle Monje-Deisseroth, Robbie Majzner, Crystal Mackall, Christopher Mount
Life of this patent
Estimating the term…
Abstract
The invention relates to immunotherapeutic treatment of cancer. In particular, the invention relates to methods of treating cancer carrying a histone H3K27M (H3K27M) mutation (e.g., diffuse midline glioma with H3K27M mutation) using immunotherapeutic compositions comprising immune cells engineered to express GD2-specific chimeric antigen receptors.
Claims18
A method of treating an individual having cancer characterized by a histone H3 K27M (H3K27M) mutation comprising administering to the individual an effective amount of immune cells genetically modified to express a chimeric antigen receptor (CAR) specific for ganglioside GD2 (GD2).
A method of treating or delaying the progression of cancer in a patient, comprising:
- a) obtaining a biological sample comprising cancer cells from the patient;
- b) determining presence of an H3K27M mutation within the cancer cells;
- and
- c) administering to the patient a therapeutically effective amount of a composition comprising T cells genetically modified to express a chimeric antigen receptor (CAR) specific for ganglioside GD2 (GD2).
Dependencies are inferred from the claim text.