Water-activated mucoadhesive compositions to reduce intestinal absorption of nutrients
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsJeffrey M. Karp, Yuhan Lee, Ali Tavakkoli, Tarawatie E. Deelman
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Abstract
This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.
Claims13
A composition comprising particles comprising an aluminum cross-linked sulfated agent, wherein the composition forms a paste with an aqueous liquid in the absence of acid, and wherein the aluminum cross-linked sulfated agent has the following chemical formula:
- C12H30Al8S8O51.(x−n)Al(OH)3.—[Al—(OH)i]m-zH2O
- wherein:
- x is less than or equal to 8;
- 0<n<x;
- m is greater than or equal to 2;
- i=1, 2, or 3;
- and
- z<3(x−n)+(6−i)m.
Dependencies are inferred from the claim text.