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US 11,433,082 B2Granted
Composition containing sulfoalkyl ether cyclodextrin and latanoprost
AssigneeCyDex Pharmaceuticals, Inc.
InventorsNaomi Esaki, James D. Pipkin
Life of this patent
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Abstract
An aqueous composition of latanoprost and SAE-CD is provided. The composition possesses improved stability over otherwise similar compositions excluding SAE-CD. Methods of and systems for treating disease, disorders, conditions or symptoms of the eye that are therapeutically responsive to latanoprost are also provided.
Claims44
An aqueous composition comprising:
- aqueous carrier;
- SAE-β-CD;
- and latanoprost, wherein the pH of the composition ranges from 6.6 to 7, and wherein the composition does not comprise hyaluronate.
A unit dose of an aqueous composition comprising:
- aqueous carrier;
- SAE-β-CD;
- latanoprost;
- and
- potassium sorbate;
- wherein the concentration of latanoprost is about 50 μg/mL;
- the concentration of the potassium sorbate is about 0.05 to about 0.2% by weight of the unit dose;
- and wherein the solution is suitable for ophthalmic administration to a subject in need thereof;
- wherein the composition does not comprise hyaluronate;
- and
- wherein the pH of the composition ranges from 6.6 to 7.
8 more elements
An aqueous composition comprising:
- aqueous carrier;
- SAE-β-CD,
- latanoprost;
- and
- one or more agents selected from one or more viscosity modifiers, one or more tonicity modifiers, one or more buffering agents, one or more buffers, one or more suspending agents, one or more gelling agents, or a combination thereof;
- wherein the composition is preservative-free;
- and
- wherein the pH of the composition ranges from 6.6 to 7.
5 more elements
Dependencies are inferred from the claim text.